An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling

Lai-Fung Chan, Sharon, Wai-Yin Sun, Raymond, Choi, Mei-Yuk, Zeng, Yibo, Shek, Lam, Sin-Yin Chui, Stephen and Che, Chi-Ming 2011. An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling. Chemical Science 2 (9) , pp. 1788-1792. 10.1039/c1sc00203a

Full text not available from this repository.

Abstract

A new trinuclear ruthenium complex [RuIII3(TSA-H)2(TSA)4][NEt4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	Royal Society of Chemistry
ISSN:	2041-6520
Date of Acceptance:	27 May 2011
Last Modified:	03 Feb 2021 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/138155

Citation Data

Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item