Alteration of polymorphic selectivity through different crystallization mechanisms occurring in the same crystallization solution

Xu, Mingcan and Harris, Kenneth David Maclean ORCID: https://orcid.org/0000-0001-7855-8598 2007. Alteration of polymorphic selectivity through different crystallization mechanisms occurring in the same crystallization solution. Journal of Physical Chemistry B 111 (30) , pp. 8705-8707. 10.1021/jp074375j

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Abstract

We report a case in which two different crystallization mechanisms occurring in the same crystallization experiment are found to yield different polymorphic outcomes. In particular, we focus on crystallization of glycine from neutral aqueous solution. Crystallization in the bulk solution gives only the metastable R-polymorph, as observed in previous studies, whereas crystallization by evaporation of a thin film of the solution on the walls of the crystallization vessel is found to give rise to the thermodynamically stable ç-polymorph, and furthermore produces an uncharacteristic crystal morphology for this polymorph. A detailed set of control experiments are described that elucidate mechanistic details relating to the latter crystallization process. The fact that crystallization on the walls of a crystallization vessel can yield a different polymorphic outcome from crystallization in the bulk solution in the same experiment has potentially much wider significance with regard to other polymorphic systems.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	ASC Publications
ISSN:	1520-6106
Last Modified:	18 Oct 2022 13:25
URI:	https://orca.cardiff.ac.uk/id/eprint/13828

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