Altering the Polymorphic Product Distribution in a Solid-State Dehydration Process by Rapid Sample Rotation in a Solid-State NMR Probe

Xu, Mingcan and Harris, Kenneth David Maclean ORCID: https://orcid.org/0000-0001-7855-8598 2005. Altering the Polymorphic Product Distribution in a Solid-State Dehydration Process by Rapid Sample Rotation in a Solid-State NMR Probe. Journal of the American Chemical Society 127 (31) , pp. 10832-10833. 10.1021/ja052668p

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Abstract

There is currently considerable interest in the phenomenon of polymorphism in organic molecular solids, and a key issue in this field is to understand the experimental techniques and procedures that may be employed to obtain new polymorphic forms of a given molecule. This paper demonstrates that the polymorphic form of a material (sodium acetate) obtained by a solid-state dehydration process (starting from sodium acetate trihydrate) can be altered by carrying out the dehydration process under conditions of rapid (several kilohertz) sample rotation in a solid-state magic-angle-spinning NMR probe. This observation suggests a new opportunity to influence the outcome of solid-state dehydration/desolvation processes and, in particular, to alter the polymorphic form of the product obtained.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	American Chemical Society
ISSN:	0002-7863
Last Modified:	18 Oct 2022 13:25
URI:	https://orca.cardiff.ac.uk/id/eprint/13839

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