Meta-selective arene C–H bond olefination of arylacetic acid using a nitrile-based directing group

Bera, Milan, Modak, Atanu, Patra, Tuhin, Maji, Arun and Maiti, Debabrata 2014. Meta-selective arene C–H bond olefination of arylacetic acid using a nitrile-based directing group. Organic Letters 16 (21) , pp. 5760-5763. 10.1021/ol502823c

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Abstract

A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C–H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	1523-7060
Last Modified:	06 May 2023 01:58
URI:	https://orca.cardiff.ac.uk/id/eprint/138424

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