Cooperative catalysis: a strategy to synthesize trifluoromethyl-thioesters from aldehydes

Mukherjee, Satobhisha, Patra, Tuhin and Glorius, Frank 2018. Cooperative catalysis: a strategy to synthesize trifluoromethyl-thioesters from aldehydes. ACS Catalysis 8 (7) , pp. 5842-5846. 10.1021/acscatal.8b01519

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Abstract

A cooperative catalysis between a photoredox and a hydrogen atom transfer (HAT) catalyst has been developed to synthesize trifluoromethylthioesters from aldehydes. This reaction is mild, highly selective, operationally simple, works under redox neutral condition, and exhibits a broad substrate scope with high functional group tolerance. The synthetic utility of this method is demonstrated by the late-stage functionalization of bioactive molecules, making it amenable for drug discovery.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	2155-5435
Last Modified:	06 May 2023 01:59
URI:	https://orca.cardiff.ac.uk/id/eprint/138434

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