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BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS

Gaud, Caroline, Sousa, Bebiana C., Nguyen, An, Fedorova, Maria, Ni, Zhixu, O'Donnell, Valerie B., Wakelam, Michael J.O., Andrews, Simon and Lopez-Clavijo, Andrea F. 2021. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Research 10 (4) 10.12688/f1000research.28022.1

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Lipidomics increasingly describes the quantitation using mass spectrometry of all lipids present in a biological sample. As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment. Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways. As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging. BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways. BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: F1000Research
ISSN: 2046-1402
Date of First Compliant Deposit: 4 March 2021
Date of Acceptance: 29 January 2021
Last Modified: 05 Mar 2021 14:30

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