Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study.

Khaleeli, Zhaleh, Olga Ciccarelli, Olga, Manfredonia, Francesco, Barkhof, Frederik, Brochet, Bruno, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Dousset, Vincent, Filippi, Massimo, Montalban, Xavier, Polman, Chris, Rovaris, Marco, Rovira, Alex, Sastre-Garriga, Jaume, Vellinga, Machteld, Miller, David and Thompson, Alan 2008. Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study. Annals of Neurology 63 (6) , pp. 790-793. 10.1002/ana.21375

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Abstract

Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Wiley
ISSN:	0364-5134
Last Modified:	09 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/139489

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