A new approach to structural integrity assessment based on axial and radial diffusivities

Wheeler-Kingshott, Claudia A. M., Ciccarelli, Olga, Schneider, Torben, Alexander, Daniel C. and Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 2012. A new approach to structural integrity assessment based on axial and radial diffusivities. Functional Neurology 27 (2) , pp. 85-90.

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Abstract

This study describes a method for performing diffusivity measures along and across a specific direction, derived from white matter in healthy controls. The diffusion tensor (DT) assigns a principal eigenvector (v₁) and eigenvalue (axial diffusivity, d(ax)) to each voxel. The average of the second and third eigenvalues is the radial diffusivity, d(rad) v₁ may be affected by pathology, therefore when comparing d(ax) and d(rad) in patients one has to consider the direction of the measurement and underlying anatomy. Here we created a representative super-DT dataset, DT(ref), whose eigenvector, v(1,ref), was considered the most likely direction of diffusivity per voxel. We defined the projected axial diffusivity, d(p-ax), as the projection of individual DTs along v(1,ref) and the projected radial diffusivity, d(p-rad), as the average of the projections along the second and third eigenvectors of DT(ref). The projected diffusivities are promising new parameters for studying white matter pathology.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Last Modified:	09 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/139508

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