Serra, Laura, Bruchini, Michela, Di Domenico, Carlotta, Mancini, Matteo, Gabrielli, Giulia Bechi, Bonarota, Sabrina, Caltagirone, Carlo, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Marra, Camillo and Bozzali, Marco 2020. Behavioral psychological symptoms of dementia and functional connectivity changes: a network-based study. Neurobiology of Aging 94 , pp. 196-206. 10.1016/j.neurobiolaging.2020.06.009 |
Abstract
Behavioral and psychological symptoms of dementia (BPSD) are commonly observed since the early stage of Alzheimer's disease (AD) associated with structural brain changes. It is conceivable that they may also relate to functional brain changes. This resting-state functional MRI (RS-fMRI) study investigated the alterations within functional brain networks of a cohort of AD patients at different clinical stages who presented with BPSD. One hundred one AD patients and 56 patients with amnestic mild cognitive impairment underwent a neuropsychological evaluation including the Neuropsychiatry Inventory-12 (NPI-12). All patients and 35 healthy controls (HS) underwent 3T-MRI. Factor analysis was used to extract the principal factors from NPI-12, while RS-fMRI data were processed using graph theory to investigate functional connectivity. Five factors were extracted from NPI-12. Sixty-two percent of patients showed BPSD and functional brain connectivity changes in various networks compared to those without BPSD and HS. These changes contributed to account for patients' BPSD. This work opens new perspectives in terms of nonpharmacological interventions that might be designed to modulate brain connectivity and improve patients' BPSD.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Psychology Cardiff University Brain Research Imaging Centre (CUBRIC) |
Publisher: | Elsevier |
ISSN: | 0197-4580 |
Date of Acceptance: | 10 July 2020 |
Last Modified: | 09 Nov 2022 10:28 |
URI: | https://orca.cardiff.ac.uk/id/eprint/139590 |
Citation Data
Cited 13 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |