The distinct roles of monoamines in multiple sclerosis: a bridge between the immune and nervous systems?

Carandini, Tiziana, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Galimberti, Daniela, Scarpini, Elio and Bozzali, Marco 2021. The distinct roles of monoamines in multiple sclerosis: a bridge between the immune and nervous systems? Brain, Behavior, and Immunity 94 , pp. 381-391. 10.1016/j.bbi.2021.02.030

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Abstract

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal actors of the interplay between the nervous and the immune system due to their ability of binding to cell-receptors of both systems, crucially regulating their function within the central nervous system and the periphery. As monoamines are dysfunctional in many neurological and psychiatric diseases, they have been successfully used as pharmacological targets. Multiple sclerosis (MS) is one of the best examples of neurological disease caused by an altered interaction between the nervous and immune system and emerging evidence supports a dysregulation of monoaminergic systems in the pathogenesis of MS, secondary to both inflammation-induced reduction of monoamines' synthesis and structural damage to monoaminergic pathways within the brain. Here we review the evidence for monoamines being key mediators of neuroimmune interaction, affecting MS pathogenesis and course. Moreover, we discuss how the reduction/dysfunction of monoamines in MS may contribute to some clinical features typical of the disease, particularly fatigue and depression. Finally, we summarize different drugs targeting monoamines that are currently under evaluation for their potential efficacy to treat MS, as well as to alleviate fatigue and depression in MS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0889-1591
Date of First Compliant Deposit:	12 April 2021
Date of Acceptance:	25 February 2021
Last Modified:	02 Dec 2024 08:15
URI:	https://orca.cardiff.ac.uk/id/eprint/139601

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