Synthesis of Novel 6-Azapyrimidine Acyclic Nucleoside Analogues and Antiviral Evaluation

Jasamai, Malina, Simons, Claire ORCID: https://orcid.org/0000-0002-9487-1100 and Balzarini, Jan 2010. Synthesis of Novel 6-Azapyrimidine Acyclic Nucleoside Analogues and Antiviral Evaluation. Nucleosides, Nucleotides & Nucleic Acids 29 (7) , pp. 535-541. 10.1080/15257771003781634

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Abstract

Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to be used as an antiviral agent in the 1990s. The acyclic moieties and the bases used in the experiment were either available commercially or synthesized using literature methods. Vorbrüggen coupling method was utilized involving reaction of persilylated heterocyclic bases with the appropriate acyclic moiety in the presence of a Lewis acid catalyst. A series of novel 6-azapyrimidine acyclic oxosugar nucleosides was successfully synthesized with a promising yield (more than 50%). An efficient method of protection and deprotection was also investigated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	Antiviral, 6-azapyrimidine acyclic nucleosides, coupling, deprotection
Publisher:	Taylor & Francis
ISSN:	1525-7770
Last Modified:	18 Oct 2022 13:28
URI:	https://orca.cardiff.ac.uk/id/eprint/13991

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