Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A human Dectin-2 deficiency associated with invasive aspergillosis

Griffiths, James S., White, P Lewis, Czubala, Magdalena A. ORCID:, Simonazzi, Elena, Bruno, Mariolina, Thompson, Aiysha, Rizkallah, Pierre J. ORCID:, Gurney, Mark ORCID:, da Fonseca, Diogo M., Naglik, Julian R., Ingram, Wendy, Wilson, Keith, van de Veerdonk, Frank L., Barnes, Rosemary, Taylor, Philip R. ORCID: and Orr, Selinda J. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224 (7) , pp. 1219-1224. 10.1093/infdis/jiab145

[thumbnail of jiab145.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview


Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immunocompromised patient. The mutated form of Dectin-2 was weakly expressed, did not form clusters at/near the cell surface and was functionally defective. PBMCs from this patient were unable to mount a cytokine (TNF, IL-6) response to A. fumigatus and this first identified Dectin-2-deficient patient succumbed to invasive aspergillosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
Publisher: University of Chicago Press / Oxford University Press (OUP)
ISSN: 0022-1899
Date of First Compliant Deposit: 24 March 2021
Date of Acceptance: 11 January 2021
Last Modified: 05 Jan 2024 06:21

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics