Zai, Clement C., Fabbri, Chiara, Hosang, Georgina M., Zhang, Ruo Su, Koyama, Emiko, de Luca, Vincenzo, Tiwari, Arun K., King, Nicole, Strauss, John, Jones, Ian  ORCID: https://orcid.org/0000-0001-5821-5889, Jones, Lisa ORCID: https://orcid.org/0000-0001-5821-5889, Breen, Gerome, Farmer, Anne E, McGuffin, Peter, Vincent, John B., Kennedy, James L. and Lewis, Cathryn M.
2021.
Genome-wide association study of suicidal behaviour severity in mood disorders.
World Journal of Biological Psychiatry
22
(9)
, pp. 722-731.
10.1080/15622975.2021.1907711
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Abstract
Objective Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (N = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
| Publisher: | Taylor and Francis |
| ISSN: | 1562-2975 |
| Date of First Compliant Deposit: | 19 May 2021 |
| Date of Acceptance: | 17 January 2021 |
| Last Modified: | 05 Dec 2024 05:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/141456 |
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