Genome-wide association study of suicidal behaviour severity in mood disorders

Zai, Clement C., Fabbri, Chiara, Hosang, Georgina M., Zhang, Ruo Su, Koyama, Emiko, de Luca, Vincenzo, Tiwari, Arun K., King, Nicole, Strauss, John, Jones, Ian, Jones, Lisa, Breen, Gerome, Farmer, Anne E, McGuffin, Peter, Vincent, John B., Kennedy, James L. and Lewis, Cathryn M. 2021. Genome-wide association study of suicidal behaviour severity in mood disorders. World Journal of Biological Psychiatry 22 (9) , pp. 722-731. 10.1080/15622975.2021.1907711

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Abstract

Objective Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (N = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Taylor and Francis
ISSN:	1562-2975
Date of First Compliant Deposit:	19 May 2021
Date of Acceptance:	17 January 2021
Last Modified:	16 May 2022 22:30
URI:	https://orca.cardiff.ac.uk/id/eprint/141456

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