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Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Erdbrügger, Uta, Blijdorp, Charles J., Bijnsdorp, Irene V., Borràs, Francesc E., Burger, Dylan, Bussolati, Benedetta, Byrd, James Brian, Clayton, Aled ORCID:, Dear, James W., Falcón-Pérez, Juan M., Grange, Cristina, Hill, Andrew F., Holthöfer, Harry, Hoorn, Ewout J., Jenster, Guido, Jimenez, Connie R., Junker, Kerstin, Klein, John, Knepper, Mark A., Koritzinsky, Erik H., Luther, James M., Lenassi, Metka, Leivo, Janne, Mertens, Inge, Musante, Luca, Oeyen, Eline, Puhka, Maija, Royen, Martin E., Sánchez, Catherine, Soekmadji, Carolina, Thongboonkerd, Visith, Steijn, Volkert, Verhaegh, Gerald, Webber, Jason P., Witwer, Kenneth, Yuen, Peter S.T., Zheng, Lei, Llorente, Alicia and Martens-Uzunova, Elena S. 2021. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles 10 (7) , e12093. 10.1002/jev2.12093

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Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License
Publisher: Wiley Open Access
ISSN: 2001-3078
Date of First Compliant Deposit: 8 June 2021
Date of Acceptance: 22 April 2021
Last Modified: 03 May 2023 03:30

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