The association between apical periodontitis and adverse pregnancy outcomes: a systematic review

Jakovljevic, A., Sljivancanin Jakovljevic, T., Duncan, H. F., Nagendrababu, V., Jacimovic, J., Aminoshariae, A., Milasin, J. and Dummer, P. M. H. ORCID: https://orcid.org/0000-0002-0726-7467 2021. The association between apical periodontitis and adverse pregnancy outcomes: a systematic review. International Endodontic Journal 54 (9) , pp. 1527-1537. 10.1111/iej.13538

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Abstract

BackgroundThe association between adverse pregnancy outcomes (APOs) and maternal apical periodontitis remains unclear as it has not been examined rigorously or reviewed systematically.ObjectiveTo systematically review and critically evaluate the available evidence on the association of maternal apical periodontitis with several APOs.MethodsA literature search was conducted using the following electronic databases: Clarivate Analytics’ Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL), from inception to 25 February 2021, with no language restrictions. Observational studies including longitudinal clinical trials, cohort, case–control and cross-sectional studies of prospective and retrospective design were included. Articles with duplicate or overlapping results, abstract-only papers, case reports, case series, animal studies and reviews were excluded. Two independent reviewers were involved in study selection, data extraction and appraising the included studies; disagreements were resolved by a third reviewer. The Newcastle–Ottawa Scale (NOS) and the adapted form of the NOS were used to assess the quality for case–control and cross-sectional studies, respectively.ResultsTwo case–control and one cross-sectional study were included in the current review. The included studies were published between 2015 and 2017, with a total of 1187 participating individuals with an approximate age range of 15 to 40 years. As the included studies reported different outcomes, the heterogeneity of data prevented a meta-analysis being undertaken. The overall quality of the evidence was ‘Fair’ for two out of three included studies, while one study was categorized as ‘Good’.DiscussionTwo out of three included primary studies had a substantial number of methodological inconsistencies and flaws, and therefore caution should be exercised in interpreting the results of this systematic review because several important covariates were not considered in the original investigations.ConclusionBased on a limited volume and ‘Fair’ and ‘Good’ quality of evidence, a positive association between maternal apical periodontitis and APOs was observed. However, more ‘Good’ quality clinical studies are needed to confirm the results of the current review.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Wiley
ISSN:	0143-2885
Date of First Compliant Deposit:	10 June 2021
Date of Acceptance:	23 April 2021
Last Modified:	06 Nov 2023 13:16
URI:	https://orca.cardiff.ac.uk/id/eprint/141841

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