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Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells

Thomson, Amanda, Costa Bento, Diana F., Scurr, Martin J. ORCID:, Smart, Kathryn, Somerville, Michelle S., Keita, Åsa V., Gallimore, Awen ORCID: and Godkin, Andrew ORCID: 2021. Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells. British Journal of Cancer 124 , pp. 1552-1555. 10.1038/s41416-021-01283-3

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Background The T cell cytokine profile is a key prognostic indicator of post-surgical outcome for colorectal cancer (CRC). Whilst TH1 (IFN-γ+) cell-mediated responses generated in CRC are well documented and are associated with improved survival, antigen-specific TH17 (IL-17A+) responses have not been similarly measured. Methods We sought to determine the cytokine profile of circulating tumour antigen-(5T4/CEA) specific T cells of 34 CRC patients to address whether antigen-specific IL-17A responses were detectable and whether these were distinct to IFN-γ responses. Results As with IFN-γ-producing T cells, anti-5T4/CEA TH17 responses were detectable predominantly in early stage (TNM I/II) CRC patients. Moreover, whilst IL-17A was always produced in association with IFN-γ, this release was mainly from two distinct T cell populations rather than by ‘dual producing’ T cells. Patients mounting both tumour-specific TH1+/TH17+ responses exhibited prolonged relapse-free survival. Conclusions Tumour antigen-specific TH17 responses play a beneficial role in preventing post-operative colorectal tumour recurrence.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer Nature [academic journals on]
ISSN: 0007-0920
Date of First Compliant Deposit: 17 June 2021
Date of Acceptance: 13 January 2021
Last Modified: 22 May 2023 20:51

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