Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

Johnson, Emma C., Kapoor, Manav, Hatoum, Alexander S., Zhou, Hang, Polimanti, Renato, Wendt, Frank R., Walters, Raymond K., Lai, Dongbing, Kember, Rachel L., Hartz, Sarah, Meyers, Jacquelyn L., Peterson, Roseann E., Ripke, Stephan, Bigdeli, Tim B., Fanous, Ayman H., Pato, Carlos N., Goate, Alison M., Kranzler, Henry R., O'Donovan, Michael C. ORCID:, Walters, James T. R. ORCID:, Gelernter, Joel, Edenberg, Howard J. and Agrawal, Arpana 2023. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 53 (4) , pp. 1196-1204. 10.1017/S003329172100266X

[thumbnail of AUDSCZ_Manuscript_Clean_20210609.pdf] PDF - Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (234kB)


Background Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders. Methods We used the largest published GWAS for AUD (total cases = 77 822) and SCZ (total cases = 46 827) to identify genetic variants that influence both disorders (with either the same or opposite direction of effect) and those that are disorder specific. Results We identified 55 independent genome-wide significant single nucleotide polymorphisms with the same direction of effect on AUD and SCZ, 8 with robust effects in opposite directions, and 98 with disorder-specific effects. We also found evidence for 12 genes whose pleiotropic associations with AUD and SCZ are consistent with mediation via gene expression in the prefrontal cortex. The genetic covariance between AUD and SCZ was concentrated in genomic regions functional in brain tissues (p = 0.001). Conclusions Our findings provide further evidence that SCZ shares meaningful genetic overlap with AUD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Cambridge University Press
ISSN: 0033-2917
Date of First Compliant Deposit: 22 June 2021
Date of Acceptance: 14 June 2021
Last Modified: 13 Nov 2023 21:06

Citation Data

Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics