Epithelial Protein Lost in Neoplasm, EPLIN, the cellular and molecular prospects in cancers

Zeng, Jianyuan, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 and Sanders, Andrew J. ORCID: https://orcid.org/0000-0002-7997-5286 2021. Epithelial Protein Lost in Neoplasm, EPLIN, the cellular and molecular prospects in cancers. Biomolecules 11 (7) , 1038. 10.3390/biom11071038

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Abstract

Epithelial Protein Lost In Neoplasm (EPLIN), also known as LIMA1 (LIM Domain And Actin Binding 1), was first discovered as a protein differentially expressed in normal and cancerous cell lines. It is now known to be key to the progression and metastasis of certain solid tumours. Despite a slow pace in understanding the biological role in cells and body systems, as well as its clinical implications in the early years since its discovery, recent years have witnessed a rapid progress in understanding the mechanisms of this protein in cells, diseases and indeed the body. EPLIN has drawn more attention over the past few years with its roles expanding from cell migration and cytoskeletal dynamics, to cell cycle, gene regulation, angiogenesis/lymphangiogenesis and lipid metabolism. This concise review summarises and discusses the recent progress in understanding EPLIN in biological processes and its implications in cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/
Publisher:	MDPI
ISSN:	2218-273X
Date of First Compliant Deposit:	16 July 2021
Date of Acceptance:	13 July 2021
Last Modified:	26 May 2023 18:06
URI:	https://orca.cardiff.ac.uk/id/eprint/142665

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