Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

Ponsford, Mark J., Jefferies, Rhys, Davies, Chris, Farewell, Daniel ORCID: https://orcid.org/0000-0002-8871-1653, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Jolles, Stephen, Fairbairn, Sara, Lewis, Keir, Menzies, Daniel, Benjamin, Amit, Thaivalappil, Favas, Williams, Chris and Barry, Simon M. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12) , pp. 1246-1249. 10.1136/thoraxjnl-2021-216964

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Abstract

The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%–35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21–63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license
Publisher:	BMJ Publishing Group
ISSN:	0040-6376
Funders:	Wellcome Trust, MRC
Date of First Compliant Deposit:	29 July 2021
Date of Acceptance:	18 June 2021
Last Modified:	18 May 2023 00:59
URI:	https://orca.cardiff.ac.uk/id/eprint/142881

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