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Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities

Metcalfe, Richard S., Kemp, Rachael, Heffernan, Shane M., Churm, Rachel, Chen, Yung-Chih, Ruffino, José S., Conway, Gillian E., Tornillo, Giusy and Orange, Samuel T. 2021. Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology and Occupational Physiology 121 (8) , 2107–2124. 10.1007/s00421-021-04680-x

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Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incubation of cancer cells with post-exercise serum can have powerful effects on key hallmarks of cancer cell behaviour in vitro. This suggests that exercise can impact tumour biology through direct changes in circulating proteins, RNA molecules and metabolites. Here, we provide a comprehensive narrative overview of what is known about the effects of exercise-conditioned sera on in vitro cancer cell behaviour. In doing so, we consider the key limitations of the current body of literature, both from the perspective of exercise physiology and cancer biology, and we discuss the potential in vivo physiological relevance of these findings. We propose key opportunities for future research in an area that has the potential to identify key anti-oncogenic protein targets and optimise physical activity recommendations for cancer prevention, treatment and survivorship.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Springer Verlag (Germany)
ISSN: 1439-6319
Date of First Compliant Deposit: 30 July 2021
Date of Acceptance: 30 March 2021
Last Modified: 09 May 2023 11:27

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