Delayed behavioral and neurochemical effects of anti-glutamate antibodies in aging C57BL/6 mice

Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L. A., Zakharova, I. A. and Sewell, R. D. E. 2021. Delayed behavioral and neurochemical effects of anti-glutamate antibodies in aging C57BL/6 mice. Bulletin of Experimental Biology and Medicine 171 (1) , 19–22. 10.1007/s10517-021-05163-x

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Abstract

We analyzed delayed effect of intranasal administration of anti-glutamate antibodies on mnestic function and tissue concentrations of neurotransmitters in the hippocampus and prefrontal cortex in aging C57BL/6 mice. It was found that after 14-day administration of anti-glutamate antibodies, improvement of the passive avoidance conditioning persisted for 7 days after the treatment was discontinued. In 7 days after discontinuation of treatment, increased content of dopamine and its metabolites as well as aspartic acid and taurine was observed in the hippocampus of mice treated with anti-glutamate antibodies. In the prefrontal cortex, administration of anti-glutamate antibodies had no effect on the levels of neurotransmitters, but increased the concentration of glutamate.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Springer Verlag
ISSN:	0007-4888
Date of First Compliant Deposit:	17 August 2021
Date of Acceptance:	28 May 2021
Last Modified:	02 Dec 2024 05:45
URI:	https://orca.cardiff.ac.uk/id/eprint/143460

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