Rizzo, Sebastiano Antonio, Bartley, Oliver, Rosser, Anne E. and Newland, Ben
2021.
Oxygen-glucose deprivation in neurons: implications for cell transplantation therapies.
Progress in Neurobiology
205
, 102126.
10.1016/j.pneurobio.2021.102126
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Abstract
Cell replacement therapies hold the potential to restore neuronal networks compromised by neurodegenerative diseases (such as Parkinson’s disease or Huntington’s disease), or focal tissue damage (via a stroke or spinal cord injury). Despite some promising results achieved to date, transplanted cells typically exhibit poor survival in the central nervous system, thus limiting therapeutic efficacy of the graft. Although cell death post-transplantation is likely to be multifactorial in causality, growing evidence suggests that the lack of vascularisation at the graft site, and the resulting ischemic host environment, may play a fundamental role in the fate of grafted cells. Herein, we summarise data showing how the deprivation of either oxygen, glucose, or both in combination, impacts the survival of neurons and review strategies which may improve graft survival in the central nervous system.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Pharmacy |
Publisher: | Elsevier |
ISSN: | 0301-0082 |
Date of First Compliant Deposit: | 23 August 2021 |
Date of Acceptance: | 27 July 2021 |
Last Modified: | 06 Oct 2021 18:47 |
URI: | https://orca.cardiff.ac.uk/id/eprint/143584 |
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