Clinical utility of telomere length measurements in cancer

Pepper, Chris, Norris, Kevin and Fegan, Christopher 2020. Clinical utility of telomere length measurements in cancer. Current Opinion in Genetics and Development 60 , pp. 107-111. 10.1016/j.gde.2020.02.012

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Abstract

Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pathologies and their responses to standard treatments. Although every tumour is to some extent distinct, there are recurrent features of cancers that can be exploited as therapeutic targets and as prognostic and predictive biomarkers; one such attribute is telomere length. Here we discuss the utility of telomere length evaluation in cancer and describe some of the promise and challenges of bringing this into clinical practice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0959-437X
Date of First Compliant Deposit:	13 September 2021
Date of Acceptance:	6 February 2020
Last Modified:	31 Jan 2022 07:56
URI:	https://orca.cardiff.ac.uk/id/eprint/144045

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