Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer

Tran, Bang Manh, Flanagan, Dustin James, Phesse, Toby James ORCID: https://orcid.org/0000-0001-9568-4916, Vincan, Elizabeth and Phesse, Toby 2021. Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer. Handbook of Experimental Pharmacology,

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Abstract

Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways, is highly conserved through evolution from the ancient phylum hydra to man, plays essential roles in stem cells, tissue homeostasis and regeneration in the adult, and is upregulated in diverse cancers. Much of what is known about the core components of the Wnt signalling pathways was derived from studying the function of Frizzled7 orthologues in the development of lower organism. As we interrogate Frizzled7 signalling and function for therapeutic targeting in cancer, it is timely to revisit lower organisms to gain insight into the context dependent and dynamic nature of Wnt signalling for effective drug design.

Item Type:	Book Section
Date Type:	Publication
Status:	In Press
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Date of First Compliant Deposit:	15 September 2021
Last Modified:	10 Nov 2022 09:43
URI:	https://orca.cardiff.ac.uk/id/eprint/144129

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