Pregnancy and perinatal outcomes for women with Cystic Fibrosis: a UK population-based cross-sectional study, 2003-2017

Esan, Oluwaseun, Schlüter, Daniella, Phillips, Rhiannon ORCID: https://orcid.org/0000-0002-4256-4598, Cosgriff, Rebecca, Parajothy, Shantini, Williams, Deni ORCID: https://orcid.org/0000-0002-2874-9270, Norman, Rachel, Carr, Siobhan, Robinson, David Taylor and Duckers, Jamie 2021. Pregnancy and perinatal outcomes for women with Cystic Fibrosis: a UK population-based cross-sectional study, 2003-2017. Authorea 10.22541/au.162182734.44469184/v1

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Abstract

Objective To estimate the pregnancy rates and outcomes for women withcystic fibrosis (wwCF) in the UK compared to the general population andto explore the impact of the introduction of disease modifyingtreatments on pregnancy rates. Design A population-based cross-sectionalstudy. Setting Electronic records of UK CF Registry Data(~99% of all CF), and conceptions data for England andWales (E&W). Population All women aged 15-44 years who were pregnantbetween 2003-2017. Methods We calculated 3-yearly crude and age-specificpregnancy rates per 1,000 women years (wys), pregnancy rates for wwCFwith a G551D mutation before and after Ivacaftor was introduced in 2012and compared live birth rates. Main outcome measures Crude rates, agespecific fertility, and maternal morbidity. Results The overallpregnancy rate was 23.5 (95% CI 21.9-25.3) per 1,000 wys,~3.4fold difference to E&W women (77.7). This patternwas evident in the age specific rates, except for those aged 40-44 yearswhere the difference in rates was much less (wwCF 8.2 per 1,000 wys vs.13.3 in E&W). LB rate differences mirrored pregnancy rates (wwCF 17.4per 1000 wys vs. 61.4 E&W women). Following the introduction ofIvacaftor, pregnancy rates in wwCF with G551D increased from 29.5 to56.9 per 1000wys (2012-2014 to 2015-2017). Conclusions Pregnancy ratesin wwCF are about a third of the rates in the general population but onthe rise following the introduction of Ivacaftor. There is no indicationthat there is a reduced chance of a live birth in wwCF who becomepregnant.

Item Type:	Article
Date Type:	Published Online
Status:	Submitted
Schools:	Medicine
Publisher:	Authorea, Inc.
Last Modified:	23 May 2023 17:07
URI:	https://orca.cardiff.ac.uk/id/eprint/144547

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