PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers

Al Thaher, Yazan, Alotaibi, Hadil Faris, Yang, Lirong and Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 2021. PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers. PLoS ONE 16 (9) , e0257947. 10.1371/journal.pone.0257947

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Abstract

Prosthetic joint infections (PJI) are still an extremely concerning eventuality after joint replacement surgery; growing antibiotic resistance is also limiting the prophylactic and treatment options. Chlorhexidine (a widely used topical non-antibiotic antimicrobial compound) coatings on silica nanoparticles capable of prolonged drug release have been successfully developed and characterised. Such nanocarriers were incorporated into commercial formulation PMMA bone cement (Cemex), without adversely affecting the mechanical performance. Moreover, the bone cement containing the developed nanocarriers showed superior antimicrobial activity against different bacterial species encountered in PJI, including clinical isolates already resistant to gentamicin. Cytocompatibility tests also showed non inferior performance of the bone cements containing chlorhexidine releasing silica nanocarriers to the equivalent commercial formulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Additional Information:	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publisher:	Public Library of Science
ISSN:	1932-6203
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 September 2021
Date of Acceptance:	15 September 2021
Last Modified:	23 May 2023 16:54
URI:	https://orca.cardiff.ac.uk/id/eprint/144574

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