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Making sense of IL-6 signalling cues in pathophysiology

Millrine, David ORCID:, Jenkins, Robert H ORCID:, Hughes, Stuart T O and Jones, Simon A ORCID: 2022. Making sense of IL-6 signalling cues in pathophysiology. FEBS Letters 596 (5) , pp. 567-588. 10.1002/1873-3468.14201

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Unravelling the molecular mechanisms that account for functional pleiotropy is a major challenge for researchers in cytokine biology. Cytokine–receptor cross-reactivity and shared signalling pathways are considered primary drivers of cytokine pleiotropy. However, reports epitomized by studies of Jak-STAT cytokine signalling identify interesting biochemical and epigenetic determinants of transcription factor regulation that affect the delivery of signal-dependent cytokine responses. Here, a regulatory interplay between STAT transcription factors and their convergence to specific genomic enhancers support the fine-tuning of cytokine responses controlling host immunity, functional identity, and tissue homeostasis and repair. In this review, we provide an overview of the signalling networks that shape the way cells sense and interpret cytokine cues. With an emphasis on the biology of interleukin-6, we highlight the importance of these mechanisms to both physiological processes and pathophysiological outcomes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License
Publisher: Elsevier
ISSN: 0014-5793
Funders: Versus Arthritis, Wellcome Trust
Date of First Compliant Deposit: 7 October 2021
Date of Acceptance: 4 October 2021
Last Modified: 17 Nov 2023 05:14

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