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Exploiting ECM remodelling to promote immune-mediated tumour destruction

Pires, Ana, Burnell, Stephanie and Gallimore, Awen ORCID: 2022. Exploiting ECM remodelling to promote immune-mediated tumour destruction. Current Opinion in Immunology 74 , pp. 32-38. 10.1016/j.coi.2021.09.006

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Cancer immunotherapy represents a significant breakthrough in cancer treatment mainly due to the ability to harness the activities of cancer-specific T cells. Despite this, most cancers remain resistant to T cell attack. Many reasons have been proposed to explain this, ranging from a lack of antigenicity through to the immunosuppressive effects of the tumour microenvironment. In this review, we examine the relationship between the immune system and a key component of the tumour microenvironment, namely the extracellular matrix (ECM). Specifically, we explore the reciprocal effects of immune cells and the tumour ECM and how the processes underpinning this relationship act to either promote or restrain tumour progression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0952-7915
Date of First Compliant Deposit: 11 November 2021
Date of Acceptance: 3 November 2021
Last Modified: 06 Nov 2023 14:07

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