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Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept

Fruchtman-Steinbok, Tom, Keynan, Jackob N., Cohen, Avihay, Jaljuli, Iman, Mermelstein, Shiri, Drori, Gadi, Routledge, Efrat, Krasnoshtein, Michael, Playle, Rebecca

, Linden, David E.J.

and Hendler, Talma 2021. Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept. NeuroImage: Clinical 32 , 102859. 10.1016/j.nicl.2021.102859

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Official URL: http://dx.doi.org/10.1016/j.nicl.2021.102859

Abstract

Amygdala activity dysregulation plays a central role in post-traumatic stress disorder (PTSD). Hence learning to self-regulate one's amygdala activity may facilitate recovery. PTSD is further characterized by abnormal contextual processing related to the traumatic memory. Therefore, provoking the personal traumatic narrative while training amygdala down-regulation could enhance clinical efficacy. We report the results of a randomized controlled trial (NCT02544971) of a novel self-neuromodulation procedure (i.e. NeuroFeedback) for PTSD, aimed at down-regulating limbic activity while receiving feedback from an auditory script of a personal traumatic narrative. To scale-up applicability, neural activity was probed by an fMRI-informed EEG model of amygdala activity, termed Amygdala Electrical Finger-Print (AmygEFP).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Additional Information:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Publisher:	Elsevier
ISSN:	2213-1582
Date of First Compliant Deposit:	12 November 2021
Date of Acceptance:	13 October 2021
Last Modified:	06 May 2023 13:51
URI:	https://orca.cardiff.ac.uk/id/eprint/145475