The effect of oestradiol implants on regional and total bone mass: a three year longitudinal study

Ryde, S. J. S., Bowen-Simpkins, K., Bowen-Simpkins, P., Evans, W. D. ORCID: https://orcid.org/0000-0003-0013-8205, Morgan, W. D. and Compston, J. E. 1994. The effect of oestradiol implants on regional and total bone mass: a three year longitudinal study. Clinical Endocrinology 40 (1) , pp. 33-38. 10.1111/j.1365-2265.1994.tb02440.x

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Abstract

Objective: Although there is evidence from cross-sectional studies that percutaneous oestrogen administration protects against menopausal bone loss, few longitudinal data are available. We have examined the effect of 3 years' treatment with percutaneous oestradiol on total body calcium, spinal trabecular bone mineral density and radial bone mineral content in post-menopausal women. Design and patients: Twenty-nine post-menopausal women, aged 37–55 years, who had undergone hysterectomy and had experienced the onset of menopausal symptoms within the previous 2 years, were studied before and for 3 years during hormone replacement with oestradiol implants, given at approximately 6-monthly intervals. Measurements: Total body calcium was measured by prompt gamma neutron activation analysis, spinal trabecular bone mineral density by quantitative computed tomography and radial bone mineral content by single-photon absorptiometry. Results: There was a significant increase in the mean total body calcium, spinal trabecular bone mineral density and radial bone mineral content over the 3 years of the study. The mean (± SEM) percentage change per annum was +2 4% (±0.8) for total body calcium (P <0 01), + 3.3% (±0.6) for spinal trabecular bone mineral density (P < 0.001) and +12% (± 0.6) for radial bone mineral content (P < 0 05). Conclusions: Percutaneous oestradiol replacement therapy prevents menopausal bone loss and is associated with a sustained and significant increase in total body calcium, spinal trabecular bone mineral density and radial bone mineral content over a 3-year treatment period. Oestradiol implants thus have skeletal effects comparable to those of oral or transdermal oestrogens.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Society for Endocrinology
ISSN:	0300-0664
Date of Acceptance:	8 June 1993
Last Modified:	10 Nov 2022 10:03
URI:	https://orca.cardiff.ac.uk/id/eprint/145528

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