Effects of antibodies to glutamate on cerebral expression of the Tnfrsf1A gene under conditions of spatial amnesia induced by proinflammatory protein S100A9 fibrils in aging mice

Gruden, M. A., Davydova, T. V., Ratmirov, A. M. and Sewell, R. D. E. 2021. Effects of antibodies to glutamate on cerebral expression of the Tnfrsf1A gene under conditions of spatial amnesia induced by proinflammatory protein S100A9 fibrils in aging mice. Bulletin of Experimental Biology and Medicine 172 (1) , 18–21. 10.1007/s10517-021-05322-0

Preview

PDF - Accepted Post-Print Version Download (195kB) | Preview

Abstract

Proinflammatory S100A9 protein is a promoter of inflammation-linked neurodegeneration and the Tnfrsf1A gene encodes the TNF receptor 1A that binds TNFα to function as a regulator of inflammation. We studied the effects of chronic intranasal administration of in vitro prepared S100A9 fibrils alone or in combination with anti-glutamate antibodies on the expression of the Tnfrsf1A gene in the hippocampus, prefrontal cortex, and cerebellum of aging C57BL/6 mice under conditions of impaired spatial memory. A differential cerebral pattern of Tnfrsf1A gene activity and its modification by S100A9 fibrillar structures were observed: inhibition of Tnfrsf1A gene expression in the hippocampus and cerebellum and its activation in the prefrontal cortex. Anti-glutamate antibodies normalized the expression of the Tnfrsf1A gene in the prefrontal cortex by affecting the TNF signaling pathway and preventing the development of inflammation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Springer Verlag
ISSN:	0007-4888
Date of First Compliant Deposit:	29 November 2021
Date of Acceptance:	1 November 2021
Last Modified:	29 Nov 2024 20:30
URI:	https://orca.cardiff.ac.uk/id/eprint/145808

Actions (repository staff only)

Edit Item