Portal hypertension in vinyl chloride monomer workers: a hemodynamic study

Blendis, L. M., Smith, P. M., Lawrie, B. W., Stephens, M. R. and Evans, W. D. ORCID: https://orcid.org/0000-0003-0013-8205 1978. Portal hypertension in vinyl chloride monomer workers: a hemodynamic study. Gastroenterology 75 (2) , pp. 206-211. 10.1016/0016-5085(78)90403-1

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Abstract

Hemodynamic studies were performed in 5 vinyl chloride monomer workers in whom splenomegaly or thrombocytopenia was detected during a screening program at major chemical plant. Three patients had portal hypertension and collateral venous circulations, with intrasplenic pressures between 20 and 29 mm Hg and normal wedged hepatic venous pressures, but the gradient between the wedged and free hepatic vein pressures was also increased. Splenic blood flows were increased in both hypertensive and normotensive patients. There was no correlation between the splenic blood flow and the portal pressure or the presence of portal fibrosis. The portal hypertension associated with vinyl chloride exposure is mainly presinusoidal in type, and may be attributed to an abnormality of the portal vein radicles, or hepatic sinusoids.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	WB Saunders
ISSN:	0016-5085
Date of Acceptance:	15 March 1978
Last Modified:	10 Nov 2022 10:16
URI:	https://orca.cardiff.ac.uk/id/eprint/146254

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