Perni, S., Piccirillo, C., Pratten, J., Prokopovich, Polina ![]() |
Abstract
We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log10 reduction in the viable count when exposed for 5 min to light from a low power 660 nm laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nm gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Engineering Pharmacy |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Uncontrolled Keywords: | Catheter; Hospital acquired infection; Polymer; Nanoparticle; Light-activated antimicrobial |
Publisher: | Elsevier |
ISSN: | 0142-9612 |
Last Modified: | 18 Oct 2022 13:37 |
URI: | https://orca.cardiff.ac.uk/id/eprint/14642 |
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