The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles

Perni, S., Piccirillo, C., Pratten, J., Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570, Chrzanowski, W., Parkin, I. P. and Wilson, M. 2009. The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30 (1) , pp. 89-93. 10.1016/j.biomaterials.2008.09.020

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Abstract

We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log10 reduction in the viable count when exposed for 5 min to light from a low power 660 nm laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nm gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Engineering Schools > Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	Catheter; Hospital acquired infection; Polymer; Nanoparticle; Light-activated antimicrobial
Publisher:	Elsevier
ISSN:	0142-9612
Last Modified:	18 Oct 2022 13:37
URI:	https://orca.cardiff.ac.uk/id/eprint/14642

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