Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

Piccirillo, C., Perni, S., Gil-Thomas, J., Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570, Wilson, M., Pratten, J. and Parkin, I. P. 2009. Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface. Journal of Materials Chemistry 19 (34) , pp. 6167-6171. 10.1039/b905495b

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Abstract

Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Publisher:	Royal Society of Chemistry
ISSN:	0959-9428
Last Modified:	02 May 2023 11:48
URI:	https://orca.cardiff.ac.uk/id/eprint/14676

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