Protocol for individual participant data meta-analysis of interventions for post-traumatic stress

Wright, Simone, Karyotaki, Eirini, Bisson, Jonathan ORCID: https://orcid.org/0000-0001-5170-1243, Cuijpers, Pim, Papola, Davide, Witteveen, Anke B., Seedat, Soraya and Sijbrandij, Marit 2022. Protocol for individual participant data meta-analysis of interventions for post-traumatic stress. BMJ Open 12 (2) , e054830. 10.1136/bmjopen-2021-054830

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Abstract

Introduction Several evidence-based treatments are effective for post-traumatic stress disorder (PTSD), yet a substantial proportion of patients do not respond or dropout of treatment. We describe the protocol for a systematic review and individual participant data meta-analysis (IPD-MA) aimed at assessing the effectiveness and adverse effects of psychotherapy and pharmacotherapy interventions for treating PTSD. Additionally, we seek to examine moderators and predictors of treatment outcomes. Method and analysis This IPD-MA includes randomised controlled trials comparing psychotherapy and pharmacotherapy interventions for PTSD. PubMed, Embase, PsycINFO, PTSDpubs and CENTRAL will be screened up till the 11th of January 2021. The target population is adults with above-threshold baseline PTSD symptoms on any standardised self-report measure. Trials will only be eligible if at least 70% of the study sample have been diagnosed with PTSD by means of a structured clinical interview. The primary outcomes of this IPD-MA are PTSD symptom severity, and response rate. Secondary outcomes include treatment dropout and adverse effects. Two independent reviewers will screen major bibliographic databases and past reviews. Authors will be contacted to contribute their participant-level datasets. Datasets will be merged into a master dataset. A one-stage IPD-MA will be conducted focusing on the effects of psychological and pharmacological interventions on PTSD symptom severity, response rate, treatment dropout and adverse effects. Subsequent analyses will focus on examining the effect of moderators and predictors of treatment outcomes. These will include sociodemographic, treatment-related, symptom-related, resilience, intervention, trauma and combat-related characteristics. By determining the individual factors that influence the effectiveness of specific PTSD treatments, we will gain insight into personalised treatment options for PTSD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information:	http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0)
Publisher:	BMJ Publishing Group
ISSN:	2044-6055
Date of First Compliant Deposit:	24 January 2022
Date of Acceptance:	5 January 2022
Last Modified:	07 May 2023 18:59
URI:	https://orca.cardiff.ac.uk/id/eprint/146862

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