Comorbid diseases and conditions in people with HIV in the UK

Jones, Bethan I., Freedman, Andrew, Thomas, Melissa J., Villalba-Mendez, Celia, Sathia, Leena, Flanagan, Deborah, Francis, Scott and Currie, Craig J. 2022. Comorbid diseases and conditions in people with HIV in the UK. Current Medical Research and Opinion 38 (2) , pp. 277-285. 10.1080/03007995.2021.2003671

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Abstract

Objectives This study aimed to characterize the risk of people living with HIV (PLHIV) in the UK progressing to pre-specified HIV-associated comorbidities, compared with matched, HIV-negative controls. Methods Primary and secondary care records from the Clinical Practice Research Datalink (CPRD) and linked Hospital Episode Statistics (HES) were used to identify PLHIV, and a matched cohort from the HIV-negative population. Kaplan Meier curves and Cox proportional hazard models were used to evaluate the risk of developing comorbidities including central nervous system (CNS) disorders, end-stage renal disease, osteoporosis, diabetes, cardiovascular disease (CVD), hypertension, stroke and cancer. Results A total of 2945 PLHIV were matched to a cohort of 5890 HIV-negative controls. PLHIV demonstrated an increased hazard ratio (HR) for time to development of incident sleep disorders, depression, osteoporosis, stroke, cancer and renal disease when compared with their matched HIV-negative control. The HRs for anxiety, hypertension, diabetes and CVD were not significantly increased. Conclusions PLHIV in the UK were at a higher risk of developing a number of comorbid conditions, highlighting the need for regular attendance of health reviews such as the annual health reviews recommended by the British HIV Associations (BHIVA) quality standard for care, which are currently not uniformly conducted.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Taylor and Francis
ISSN:	0300-7995
Date of First Compliant Deposit:	26 January 2022
Date of Acceptance:	4 November 2021
Last Modified:	02 May 2023 19:57
URI:	https://orca.cardiff.ac.uk/id/eprint/146953

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