The discovery and development of small molecule immunomodulators as potential therapeutics

Xu, Qin 2021. The discovery and development of small molecule immunomodulators as potential therapeutics. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Cancer immunotherapy has become a new generation of cancer treatment as it implicated the involvement of key components from the immune system to fight cancer. While this field is thriving, a subset of T cells termed gamma delta T cells (γδ T cells) is now starting to receive attention in the development of immunotherapeutics. γδ T cells shares no similarity with the common αβ T cells in terms of antigen recognition. Indeed, antigen recognition by γδ T cells does not reliy on the MHC/HLA (major histocompatibility complex or human leukocyte antigen) system. These cells recognise non-peptidic small-phosphorus-containing-molecules (called phosphoantigens) leading to their activation. This thesis focuses on the phosphoantigen-derived activation of γδ T cells to discover and develop new molecules that could activate γδ T cells as potential cancer immunotherapeutics. To achieve this, a series of γδ T cell activators were designed and synthesised, and their drug-like properties were optimised. Encouragingly, these activators exhibited potent activation of γδ T cell and effective lysis of cancer cells. Overall, this study provides important preclinical data on a new class of γδ T cell activators that have the potential to treat cancer.

Item Type:	Thesis (PhD)
Date Type:	Completion
Status:	Unpublished
Schools:	Pharmacy
Subjects:	Q Science > Q Science (General)
Date of First Compliant Deposit:	7 February 2022
Last Modified:	11 Mar 2023 02:29
URI:	https://orca.cardiff.ac.uk/id/eprint/147276

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