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Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Nguyen, Thi H. O., Koutsakos, Marios, van de Sandt, Carolien E., Crawford, Jeremy Chase, Loh, Liyen, Sant, Sneha, Grzelak, Ludivine, Allen, Emma K., Brahm, Tim, Clemens, E. Bridie, Auladell, Maria, Hensen, Luca, Wang, Zhongfang, Nüssing, Simone, Jia, Xiaoxiao, Günther, Patrick, Wheatley, Adam K., Kent, Stephen J., Aban, Malet, Deng, Yi-Mo, Laurie, Karen L., Hurt, Aeron C., Gras, Stephanie, Rossjohn, Jamie, Crowe, Jane, Xu, Jianqing, Jackson, David, Brown, Lorena E., La Gruta, Nicole, Chen, Weisan, Doherty, Peter C., Turner, Stephen J., Kotsimbos, Tom C., Thomas, Paul G., Cheng, Allen C. and Kedzierska, Katherine 2021. Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients. Nature Communications 12 (1) , 2691. 10.1038/s41467-021-23018-x

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Abstract

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels. Influenza disease correlates with increases in IL-6/IL-8/MIP-1α/β cytokines and lower antibody responses. Robust activation of circulating T follicular helper cells correlates with peak antibody-secreting cells and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccination-induced B-cell responses. Numbers of influenza-specific CD8+ or CD4+ T cells increase early in disease and retain an activated phenotype during patient recovery. We report the characterisation of immune cellular networks underlying recovery from influenza infection which are highly relevant to other infectious diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Nature Research
ISSN: 2041-1723
Date of First Compliant Deposit: 9 February 2022
Date of Acceptance: 8 April 2021
Last Modified: 17 Feb 2022 15:00
URI: https://orca.cardiff.ac.uk/id/eprint/147358

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