Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release

Kidd, Emma ORCID: https://orcid.org/0000-0001-5507-1170, Garratt, J. C. and Marsden, C. A. 1991. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European Journal of Pharmacology 200 (1) , pp. 131-139. 10.1016/0014-2999(91)90675-G

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Abstract

These experiments were designed to examine the effects of repeated l-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) treatment on the autoregulatory control of cortical 5-HT release and dorsal raphe nucleus (DRN) 5-HT neuronal cell firing. Repeated DOI treatment decreased the behavioural responsiveness (wet-dog shakes) of 5-HT2, receptors and attenuated the inhibitory effects of the 5-HT1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), on both cortical 5-HT release and DRN 5-HT neuronal firing. In contrast, the inhibitory effect of acute DOI on cortical 5-HT release and DRN 5-HT neuronal firing was unaffected by repeated DOI treatment. The results demonstrate that changes in the responsiveness of 5-HT2 receptor function may influence the responsiveness of presynaptic 5-HT1A receptors regulating 5-HT neuronal function. The results also provide further evidence that the inhibition of cortical 5-HT release and DRN 5-HT neuronal firing produced by DOI is not mediated by 5-HT2 receptor activation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	5-HT release in vivo; Dorsal raphe nucleus; 5-HT neuronal firing; DOI (l-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane); 5-HT2/5-HT1A receptor interaction
Publisher:	Elsevier
ISSN:	0014-2999
Last Modified:	18 Oct 2022 13:38
URI:	https://orca.cardiff.ac.uk/id/eprint/14755

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