Image-guided magnetic thermoseed navigation and tumor ablation using a magnetic resonance imaging system

Baker, Rebecca R., Payne, Christopher, Yu, Yichao, Mohseni, Matin, Connell, John J., Lin, Fangyu, Harrison, Ian F., Southern, Paul, Rudrapatna, Umesh S., Stuckey, Daniel J., Kalber, Tammy L., Siow, Bernard, Thorne, Lewis, Punwani, Shonit, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Emberton, Mark, Pankhurst, Quentin A. and Lythgoe, Mark F. 2022. Image-guided magnetic thermoseed navigation and tumor ablation using a magnetic resonance imaging system. Advanced Science 9 (12) , 2105333. 10.1002/advs.202105333

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Abstract

Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image-guided remote-control of magnetically labeled therapies and devices in the body, using a magnetic resonance imaging (MRI) system. Minimally INvasive IMage-guided Ablation (MINIMA), a novel, minimally invasive, MRI-guided ablation technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an MRI scanner, before inducing localized cell death using an MR-compatible thermoablative device. The authors demonstrate precise thermoseed imaging and navigation through brain tissue using an MRI system (0.3 mm), and they perform thermoablation in vitro and in vivo within subcutaneous tumors, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel theranostic platform, combining imaging, navigation, and heating to deliver diagnosis and therapy in a single device.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License
Publisher:	Wiley Open Access
ISSN:	2198-3844
Date of First Compliant Deposit:	2 March 2022
Last Modified:	02 May 2023 19:53
URI:	https://orca.cardiff.ac.uk/id/eprint/147786

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