Towards a more realistic and flexible white matter numerical phantom generator for diffusion MRI simulation

Callaghan, Ross, Shemesh, Noam, Alexander, Daniel, Zhang, Hui and Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967 2019. Towards a more realistic and flexible white matter numerical phantom generator for diffusion MRI simulation. Presented at: ISMRM 27th Annual Meeting and Exhibition, 11-16 May 2019.

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Abstract

We present a novel method for the generation of realistic white matter numerical phantoms with controllable morphology, and more realistic orientation-dispersion and packing-density. A shift of paradigm is proposed: rather than ‘packing fibres’, our algorithm ‘grows fibres’ contextually and efficiently, avoiding intersection between fibres. The potential of the method is demonstrated by reaching the highest orientation-dispersion and packing-density ever. The flexibility of the method is demonstrated with simulations of diffusion-weighted MR signal in three example substrates with differing orientation-dispersions, packing-densities and permeabilities. A proof-of-concept application is presented to investigate the impacts of undulation and beading on the intra-axonal axial diffusivity.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Completion
Status:	Unpublished
Schools:	Schools > Psychology
Last Modified:	10 Nov 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/147868

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