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Evaluation of plaque burden and in atherosclerotic plaques

Chan, Yee-Hung, Alahmadi, Alaa, Alotibi, Reem and Ramji, Dipak P. 2022. Evaluation of plaque burden and in atherosclerotic plaques. Atherosclerosis: Methods and Protocols, Vol. 2419. Methods in Molecular Biology, Springer, pp. 481-496. (10.1007/978-1-0716-1924-7_29)

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Abstract

Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid-rich, fibrous plaques within the arterial wall of medium and large arteries. Plaques prone to rupture are typically rich in lipids and pro-inflammatory markers. Cells within the plaque can take up lipids via different mechanisms leading to the formation and accumulation of lipid-rich foam cells, a key hallmark of the disease. Evaluation of plaque burden and lipid content is hence important to determine disease progression and severity. This chapter describes the most commonly used staining methods that enable visualization and analysis of mouse atherosclerotic plaques. These methods include en face preparation of mouse aorta, and staining sections of arteries using hematoxylin and eosin, Oil Red O, and Masson’s Trichrome.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer
ISBN: 9781071619247
ISSN: 1064-3745
Last Modified: 30 Apr 2022 16:03
URI: https://orca.cardiff.ac.uk/id/eprint/148032

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