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Key roles of inflammation in atherosclerosis: mediators involved in orchestrating the inflammatory response and its resolution in the disease along with therapeutic avenues targeting inflammation

Chan, Yee-Hung and Ramji, Dipak P. 2022. Key roles of inflammation in atherosclerosis: mediators involved in orchestrating the inflammatory response and its resolution in the disease along with therapeutic avenues targeting inflammation. In: Ramji, Dipak ed. Atherosclerosis: Methods and Protocols, Vol. 2419. Methods in Molecular Biology, New York, NY: Springer, pp. 21-37. (10.1007/978-1-0716-1924-7_2)

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Abstract

Inflammation is a critical driver of all stages of atherosclerosis, from lesion development to plaque rupture. Cytokines are mediators of the immune response and in atherosclerosis, the balance of anti- and pro-inflammatory cytokines is tipped in favor of the latter, resulting in persistent and unresolved inflammation. Although reducing plasma cholesterol levels mainly via the use of statins has positively impacted patient outcomes and reduced mortality rates, the presence of significant residual inflammation and cardiovascular risk posttherapy emphasizes the prevailing risk of primary and secondary events driven by inflammation independently of hyperlipidemia. Given the dominant role of inflammation in driving pathogenesis, alternative therapeutic avenues beyond targeting lowering of plasma lipids are required. This chapter will discuss the role of inflammation and pro-inflammatory cytokines in driving atherogenesis and disease progression, the therapeutic potential of targeting cytokines for atherosclerosis and promising avenues in this area.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer
ISBN: 9781071619230
ISSN: 1064-3745
Last Modified: 09 Mar 2022 16:45
URI: https://orca.cardiff.ac.uk/id/eprint/148039

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