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Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis

Menendez-Gonzalez, Juan Bautista and Rodrigues, Neil P. 2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. In: Ramji, Dipak ed. Atherosclerosis, Vol. 2419. Methods in Molecular Biology, Springer, pp. 73-88. (10.1007/978-1-0716-1924-7_5)

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Abstract

Outgrowth of a mutated hematopoietic stem/progenitor clone and its descendants, also known as clonal hematopoiesis, has long been considered as either a potential forerunner to hematologic malignancy or as a clinically silent phase in leukemia that antedates symptomatic disease. That definition of clonal hematopoiesis has now been expanded to encompass patients who harbor specific genetic/epigenetic mutations that lead to clonal hematopoiesis of indeterminate potential (CHIP) and, with it, a relatively heightened risk for both myeloid malignancy and atherosclerosis during aging. In this review, we provide contemporary insights into the cellular and molecular basis for CHIP and explore the relationship of CHIP to myeloid malignancy and atherosclerosis. We also discuss emerging strategies to explore CHIP biology and clinical targeting of CHIP related malignancy and cardiovascular disease.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer
ISBN: 9781071619247
ISSN: 1064-3745
Last Modified: 14 Mar 2022 11:00
URI: https://orca.cardiff.ac.uk/id/eprint/148113

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