Infection history and current co-infection with Schistosoma mansoni decreases Plasmodium species intensities in pre-school children from Uganda

McDowell, Daniel, Hurt, Lisa ORCID: https://orcid.org/0000-0002-2741-5383, Kabatereine, Narcis B., Stothard, John Russell and Lello, Joanne ORCID: https://orcid.org/0000-0002-2640-1027 2022. Infection history and current co-infection with Schistosoma mansoni decreases Plasmodium species intensities in pre-school children from Uganda. Journal of Infectious Diseases 225 (12) , pp. 2181-2186. 10.1093/infdis/jiac072

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Abstract

Malaria-schistosomiasis co-infections are common in sub-Saharan Africa but studies present equivocal results regarding the inter-specific relationships between these parasites. Through mixed model analyses of a dataset of Ugandan preschool children, we explore how current co-infection and prior infection with either Schistosoma mansoni or Plasmodium species, alter subsequent 1) Plasmodium intensity 2) Plasmodium risk and 3) S. mansoni risk. Co-infection and prior infections with S. mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Biosciences
Additional Information:	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher:	Oxford University Press
ISSN:	0022-1899
Funders:	Wellcome Trust
Date of First Compliant Deposit:	11 March 2022
Date of Acceptance:	23 February 2022
Last Modified:	28 Jul 2024 17:42
URI:	https://orca.cardiff.ac.uk/id/eprint/148326

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