Fluorescence-based methods for detecting caries lesions: Systematic review, meta-analysis and sources of heterogeneity

Gimenez, T., Braga, M.M., Raggio, D.P. ORCID: https://orcid.org/0000-0002-0048-2068, Deery, C., Ricketts, D.N. and Mendes, F.M. 2013. Fluorescence-based methods for detecting caries lesions: Systematic review, meta-analysis and sources of heterogeneity. PLoS ONE 8 (4) , e60421.. 10.1371/journal.pone.0060421

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Abstract

Background: Fluorescence-based methods have been proposed to aid caries lesion detection. Summarizing and analysing findings of studies about fluorescence-based methods could clarify their real benefits. Objective: We aimed to perform a comprehensive systematic review and meta-analysis to evaluate the accuracy of fluorescence-based methods in detecting caries lesions. Data Source: Two independent reviewers searched PubMed, Embase and Scopus through June 2012 to identify papers/ articles published. Other sources were checked to identify non-published literature. Study Eligibility Criteria, Participants and Diagnostic Methods: The eligibility criteria were studies that: (1) have assessed the accuracy of fluorescence-based methods of detecting caries lesions on occlusal, approximal or smooth surfaces, in both primary or permanent human teeth, in the laboratory or clinical setting; (2) have used a reference standard; and (3) have reported sufficient data relating to the sample size and the accuracy of methods. Study Appraisal and Synthesis Methods: A diagnostic 262 table was extracted from included studies to calculate the pooled sensitivity, specificity and overall accuracy parameters (Diagnostic Odds Ratio and Summary Receiver-Operating curve). The analyses were performed separately for each method and different characteristics of the studies. The quality of the studies and heterogeneity were also evaluated. Results: Seventy five studies met the inclusion criteria from the 434 articles initially identified. The search of the grey or nonpublished literature did not identify any further studies. In general, the analysis demonstrated that the fluorescence-based method tend to have similar accuracy for all types of teeth, dental surfaces or settings. There was a trend of better performance of fluorescence methods in detecting more advanced caries lesions. We also observed moderate to high heterogeneity and evidenced publication bias. Conclusions: Fluorescence-based devices have similar overall performance; however, better accuracy in detecting more advanced caries lesions has been observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Public Library of Science
ISSN:	1932-6203
Date of First Compliant Deposit:	24 June 2022
Last Modified:	24 May 2023 14:28
URI:	https://orca.cardiff.ac.uk/id/eprint/148823

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