Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Cohen-Adad, J., Alonso-Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., Barry, R.L., Barth, M., Battiston, M., Buchel, C., Budde, M., Callot, V., Combes, A.J.E., De Leener, B., Descoteaux, M., de Sousa, P.L., Dostal, M., Doyon, J., Dvorak, A., Eippert, F., Epperson, K.R., Epperson, K.S., Freund, P., Finsterbusch, J., Foias, A., Fratini, M., Fukunaga, I., Gandini Wheeler-Kingshott, C.A.M., Germani, G., Gilbert, G., Giove, F., Gros, C., Grussu, F., Hagiwara, A., Henry, P.-G., Horak, T., Hori, M., Joers, J., Kamiya, K., Karbasforoushan, H., Kekovsk, M., Khatibi, A., Kim, J.-W., Kinany, N., Kitzler, H.H., Kolind, S., Kong, Y., Kudlika, P., Kuntke, P., Kurniawan, N.D., Kusmia, S., Labounek, R., Lagan, Lagana, Tackley, George ORCID: https://orcid.org/0000-0002-7464-7662 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2021. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific Data 8 (1) , 219. 10.1038/s41597-021-00941-8

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Abstract

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Nature Research
ISSN:	2052-4463
Date of First Compliant Deposit:	14 April 2022
Date of Acceptance:	26 March 2021
Last Modified:	06 Dec 2024 22:21
URI:	https://orca.cardiff.ac.uk/id/eprint/149181

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