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Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Cohen-Adad, J., Alonso-Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., Barry, R.L., Barth, M., Battiston, M., Buchel, C., Budde, M., Callot, V., Combes, A.J.E., De Leener, B., Descoteaux, M., de Sousa, P.L., Dostal, M., Doyon, J., Dvorak, A., Eippert, F., Epperson, K.R., Epperson, K.S., Freund, P., Finsterbusch, J., Foias, A., Fratini, M., Fukunaga, I., Gandini Wheeler-Kingshott, C.A.M., Germani, G., Gilbert, G., Giove, F., Gros, C., Grussu, F., Hagiwara, A., Henry, P.-G., Horak, T., Hori, M., Joers, J., Kamiya, K., Karbasforoushan, H., Kekovsk, M., Khatibi, A., Kim, J.-W., Kinany, N., Kitzler, H.H., Kolind, S., Kong, Y., Kudlika, P., Kuntke, P., Kurniawan, N.D., Kusmia, S., Labounek, R., Lagan, Lagana, Tackley, George ORCID: and Wise, Richard G. ORCID: 2021. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific Data 8 (1) , 219. 10.1038/s41597-021-00941-8

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In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Nature Research
ISSN: 2052-4463
Date of First Compliant Deposit: 14 April 2022
Date of Acceptance: 26 March 2021
Last Modified: 11 Aug 2023 16:15

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