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Postural control and gait measures derived from wearable inertial measurement unit devices in Huntington's disease: recommendations for clinical outcomes

Desai, Radhika, Blacutt, Miguel, Youdan, Greg, Fritz, Nora E., Muratori, Lisa, Hausdorff, Jeffrey M., Busse, Monica ORCID: and Quinn, Lori ORCID: 2022. Postural control and gait measures derived from wearable inertial measurement unit devices in Huntington's disease: recommendations for clinical outcomes. Clinical Biomechanics 96 , 105658. 10.1016/j.clinbiomech.2022.105658

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Background Postural control impairments begin early in Huntington's disease yet measures most sensitive to progression have not been identified. The aims of this study were to: 1) evaluate postural control and gait in people with and without Huntington's disease using wearable sensors; and 2) identify measures related to diagnosis and clinical severity. Methods 41 individuals with Huntington's disease and 14 age-matched peers performed standing with feet together and feet apart, sitting, and walking with wearable inertial sensors. One-way analysis of variance determined differences in measures of postural control and gait between early and mid-disease stage, and age-matched peers. A random forest analysis identified Features of Importance for Huntington's disease diagnosis. Stepwise and ordinal regressions were used to determine predictors of clinical chorea and tandem walking scores respectively. Findings There was a significant main effect for all postural control and gait measures comparing early stage, mid stage and age-matched peers, except for gait cycle duration and step duration. Total sway, root mean square and mean velocity during sitting, as well as gait speed had the greatest importance in classifying disease status. Stepwise regression showed that root mean square during standing with feet apart significantly predicted clinical measure of chorea, and ordinal regression model showed that root mean square and total sway standing feet together significantly predicted clinical measure of tandem walking. Interpretations Root mean square measures obtained in sitting and standing using wearable sensors have the greatest potential to serve as biomarkers of postural control impairments in Huntington's disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Centre for Trials Research (CNTRR)
Publisher: Elsevier
ISSN: 0268-0033
Date of First Compliant Deposit: 26 April 2022
Date of Acceptance: 22 April 2022
Last Modified: 07 Nov 2023 03:52

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